刘昌胜(重庆大学校长（副部长级）、党委副书记)

刘昌胜，1967年6月生，男，湖北黄石人，1989年毕业于湖北大学生物系本科，1992年获华东化工学院硕士学位。生物材料学家，中国科学院院士，现任重庆大学校长（副部长级）、党委副书记。

1996年获华东理工大学博士学位，2000年入选教育部跨世纪优秀人才，2001年任医用生物材料教育部工程研究中心主任，2004年获国家杰出青年科学基金资助，2009年任华东理工大学材料科学与工程学院院长，2015年任华东理工大学党委常委、副校长，2017年当选中国科学院院士，2019年任上海大学校长、中共上海大学委员会副书记。2025年11月，任重庆大学校长（副部长级）、党委副书记。

刘昌胜长期从事生物材料的基础与应用研究，发展了多种活性骨修复材料以及生长因子制备和材料活化新技术；所研制的自固化磷酸钙人工骨获产品注册证并已在临床上获得广泛应用。

个人经历

学习经历

1967年6月出生于湖北省大冶县；1982年至1985年在湖北理工学院师范学院学习；1985年保送湖北大学学习；1989年毕业于湖北大学生物学专业，获理学学士学位。

1992年毕业于华东理工大学生物化工专业，获工学硕士学位。

1996年毕业于华东理工大学化学工程专业，获工学博士学位。

工作经历

1992年7月至1993年2月，华东理工大学生工系助教。

1993年至1999年，在华东理工大学技物所，历任助教、讲师、副教授、教授，研究室主任、副所长、党支部书记。

1999年至2008年，任华东理工大学材料科学与工程学院生物材料研究所所长，教授，博士生导师。

2001年起，担任教育部医用生物材料工程研究中心主任，其中，2005年3月至9月，美国University of Pennsylvania访问教授。

2009年，任华东理工大学材料科学与工程学院院长。

2012年，承担国家重大科学研究计划项目任首席科学家。国家自然科学基金委创新群体学术带头人。12月，当选华东理工大学第十届党委委员，校学术委员会委员、校学位委员会委员。

2015年7月，任华东理工大学党委常委、副校长。同月，入选中国科学院院士增选初步候选人名单。

2017年11月，当选中国科学院院士。

2018年4月，当选美国医学与生物工程院会士（AIMBE Fellow）。

2019年6月，担任上海大学校长、中共上海大学委员会副书记。

2021年12月，任上海市第十五届人民代表大会代表。

2022年12月，任上海市第十六届人民代表大会代表。

2025年11月，任重庆大学校长（副部长级）、党委副书记。

社会任职

国际生物材料学会联合会会士，美国医学与生物工程院会士。国家“纳米科技”专项总体专家组成员，国务院学位评议委员会第八届材料科学与工程学科评议组委员，教育部科技委材料学部委员，教育部高等学校教学指导委员会材料类专业教学指导委员会副主任，中国生物材料学会理事长、上海市科创启明星协会理事长、中国生物医学工程学会常务理事，中国复合材料学会生物复合材料专业委员会委员、中国生物材料专业委员会委员、中国生物医学工程学会生物材料专业委员会委员、中国材料学会生物材料分会理事、上海硅酸盐学会生物材料与环境材料专业委员会主任委员、上海市生物医学工程学会生物材料专业委员会副主任委员；上海市科技启明星联谊会副秘书长、上海大学附属中学名誉校长、英国伦敦玛丽女王大学工程与材料科学学院名誉教授等职。

研究方向

长期从事生物材料的基础与应用研究，发展了多种活性骨修复材料以及生长因子制备和材料活化新技术；所研制的自固化磷酸钙人工骨获产品注册证并已在临床上获得广泛应用。

主要成就

科研综述

在国家“863”项目等二十余项项目的支持下，一直从事硬组织生物材料的研究和产业化工作。研制出具有塑型准确、自行固化、生物相容性好和降解吸收等特性统一的自固化磷酸钙“人工骨”系列产品，获得了国家药品监督管理局第一张此类产品的准生产批文，改变了长期以来骨缺损治疗中“以创伤治创伤”的“挖肉补疮”模式，也改变了牙齿根管治疗的传统概念，被国际同行评价为“处于骨再生修复技术前沿”，在骨肿瘤、创伤、脊柱外科、口腔科等领域都取得了满意的效果，其应用具有巨大的经济效益和重大的社会效益。

申请发明专利71项，其中授权发明专利50项（美国授权专利4项）。发表SCI收录论文300余篇，包括Chemical Review、Science Advances、Biomaterials等本领域著名期刊40余篇。出版中、英文专著（教材）5本。

学术研究

从事人体硬组织修复材料的研究和开发，以及纳米生物材料的研究工作。作为项目负责人，先后承担了国家“863”项目、国家自然科学基金重点及面上项目、国家重大科学研究计划项目等，将化学反应工程的原理和方法用于人体组织修复材料的可控制备及相关机理研究，开发出一种新型硬组织修复材料——自固化磷酸钙人工骨产品，并于2000年获得国家食品药品监督管理局的准生产注册证。该材料实现了形状任意可塑、人体内自行硬化和好的生物相容性的统一，并在体内诱导新骨形成，解决了长期以来困扰骨科医生和病人的骨缺损修复材料问题。新材料可广泛用于骨科、整形科、脑外科及口腔科等领域。经上海市科技情报所检索，未见与该成果相同的已获注册许可证的同类产品报道。该材料由多种磷酸钙盐组成，用自制的固化液，可调和成糊状，能根据骨缺损部位，任意塑形、充填，最终成份可转化为低结晶度的羟基磷灰石。材料经体外试验和体内长期植人试验，表明材料无毒，无致癌、致畸形活性，与有机体亲和性好，植入后不引起异物反应，具有可降解性，在软组织中无成骨活性，但在骨膜下能引导成骨生长。是生物相容性高、性能好的骨修复材料。各项性能指标达到甚至部分超过国外类似产品的水平。已在全国500余家医院广泛使用。临床医生标明采用该材料进行基础和应用研究发表论文250余篇。

为了进一步提高材料的成骨活性，适应大段骨缺损及再生能力弱的病人的治疗要求，他采用基因工程技术，在原核生物中成功表达出骨形态发生蛋白-2（rhBMP-2），一种促进成骨的活性生长因子。通过攻克重组菌株的发酵和蛋白纯化、精制等过程的系列关键技术，得到高纯度rhBMP-2产品，实现生产稳定，经国外机构检测证实成骨活性高。获美国、中国授权等专利授权。将rhBMP-2用于骨修复材料的活性化修饰，突破了生长因子活性维持和控释等关键难题，制备出具有高成骨活性的骨修复材料。临床研究病例显示出优良的治疗效果，可明显促进骨生成，加速骨愈合。这对大段骨缺损及骨再生能力弱患者的治疗具有重要意义。创新性地提出利用材料与生长因子的相互作用提高生长因子骨诱导活性的新思路，通过类肝素磺化壳聚糖等，能有效提高rhBMP-2诱导成骨分化的能力，并研究了其机理。

人物专著

【代表性专著/国家精品视频公开课】

1. 刘昌胜等著，纳米生物材料，科学出版社，2021年7月出版

2. 刘昌胜等著, Developments and Applications of Calcium Phosphate Bone Cements, Springer, 2017

3. 刘昌胜等著，硬组织修复材料与技术，科学出版社，2014年8月出版

4. 刘昌胜等著，纳米微囊型血液代用品，科学出版社，2014年6月出版

5. 刘昌胜主编，生物医学工程，华东理工大学出版社，2012年出版

6.刘昌胜，生物医用材料，国家精品视频公开课(2013年)

科研项目

(1) 国家自然科学基金委员会, 创新研究群体项目, 51621002, 无机纳米生物材料, 2017-01-01 至 2022-12-31, 1050万元, 在研, 主持

(2) 教育部, 高等学校学科创新引智计划资助, B14018, 生物材料与工程创新引智基地, 2014-01 至 2023-12, 900万元, 在研, 主持

(3) 国家自然科学基金委员会, 重点项目, 31330028, 骨修复生物活性材料与宿主微环境的相互作用, 2014-01 至 2018-12, 296万元, 结题, 主持

主要论文

1.Jinyang Li, Xue Qu, Gregory F. Payne, Cheng Zhang, Yuxin Zhang, Jianbo Li, Jie Ren, Hua Hong, Changsheng Liu, Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery, Adv. Funct. Mater. 2015, DOI: 10.1002/adfm.201403636

2.Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing, Changsheng Liu, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2, Biomaterials, 2014, 35(2):684-698

3 .Lingyan Cao, Jerome A. Werkmeister, Jing Wang, Veronica Glattauer, Keith M. McLean*, Changsheng Liu*, Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated 几丁聚糖 nanoparticles, Biomaterials, 2014,35(9): 2730-2742

4.Fan Yang, Jing Wang, Juan Hou, Han Guo, Changsheng Liu, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2步兵战车, Biomaterials, 2013, 34: 1514-1528

5.Jing Zhang, Huanjun Zhou, Kai Yang, Yuan Yuan*, Changsheng Liu*, RhBMP-2-loaded 钙硅酸盐/calcium 磷酸盐 cement 脚手架 with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 2013, 34: 9381-9392

6.Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang, Enhanced Healing of Rat Calvarial Defects with Sulfated 几丁聚糖Coated 钙Deficient 羟基磷灰石/Bone Morphogenetic Protein 2 Scaffolds, Tissue Engineering Part A, 2012, 18(1-2): 185-197

7.Deliang Zeng, Lunguo Xia, Wenjie Zhang, Hui Huang, Bin Wei, Qingfeng Huang, Jie Wei, Changsheng Liu, Xinquan Jiang, Maxillary Sinus Floor Elevation Using a Tissue-Engineered Bone with 钙镁磷酸盐 Cement and Bone Marrow Stromal Cells in Rabbits, Tissue Engineering Part A, 2012, 18(7-8): 870-882

8 .Derong Zou, Lian Guo, Jiayu Lu, Xiuli Zhang, Jie Wei, Changsheng Liu, Zhiyuan Zhang, Xinquan Jiang, Engineering of Bone Using Porous 钙 Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats, Tissue Engineering Part A, 2012, 18(13-14): 1464-1478

9 .Chenglong Dai, Han Guo, Jingxiong Lu, Jianlin Shi, Jie Wei, Changsheng Liu*, Osteogenic evaluation of 钙/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2步兵战车 by synchrotron radiation-based mCT, Biomaterials, 2011, 32: 8506-8517

10.Wenjie Dong , Yongsheng Li*, Dechao Niu , Zhi Ma , Jinlou Gu , Yi Chen , Wenru Zhao ,Xiaohang Liu , Changsheng Liu , and Jianlin Shi*, Facile Synthesis of Monodisperse Superparamagnetic 四氧化三铁 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy, Adv. Mater. 2011, 23, 5392–5397

11.Qi Gan, Xunyu Lu, Yuan Yuan, Jiangchao Qian, Huanjun Zhou, Xun Lu, Jianlin Shi, Changsheng Liu*, A magnetic, reversible pH-responsive nanogated ensemble based on 四氧化三铁 nanoparticles-capped mesoporous silica, Biomaterials, 2011, 32: 1932-1942.

12.Yuan Yuan, Changsheng Liu*, Jiangchao Qian, Jing Wang, Yuan Zhang, Size-mediated cytotoxicity and apoptosis of 羟基磷灰石 nanoparticles in human hepatoma HepG2 cells, Biomaterials, 2010, 31:730-740.

13.Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu*, Hierarchically microporous/macroporous scaffold of magnesium–钙磷酸盐 for bone tissue regeneration, Biomaterials, 2010, 31:1260-1269.

14.Chenglong Dai, Changsheng Liu*, Jie Wei, Hua Hong, Qinghui Zhao, Molecular imprinted macroporous 几丁聚糖 coated mesoporous silica xerogels for hemorrhage control, Biomaterials, 2010, 31:7620-7630.

15.Yan Sheng, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou, Feng Xu，Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and H₂Osoluble chitosan. Biomaterials, 2009, 30: 2340-2348.

16.Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su, Changsheng Liu*, Preparation and characterization of bioactive mesoporous wollastonite – Polycaprolactone composite 脚手架 Biomaterials, 2009,30:1080-1088.

17.Huanjun Zhou, Jiangchao Qian, Jing Wang, Wantong Yao, Changsheng Liu*, Jianguo Chen, Xuehua Cao，Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N,6-O-sulfated chitosan in vitro and in vivo，Biomaterials，2009,30:1715-1724.

18.Chenglong Dai, Yuan Yuan, Changsheng Liu*, Jie Wei, Hua Hong, Xiaosheng Li, Xiaohua Pan, Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control, Biomaterials, 2009, 30: 5364-5375.

19.Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Development of mussel adhesive polypeptide mimics coating for in-situ inducing re-endothelialization of intravascular stent devices, Biomaterials, 2009, 30 :2764-2773.

20.Jing Wang, Changsheng Liu*, Xin Lu, Min Yin, Copolypeptides of 3,4-Dihydroxypheny- lalanine and L-lysline to Mimic Marine Adhesive Protein, Biomaterials, 2007, 28:3456-3468.

21.Jian Zhao, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Xiaoqian Shan, Yan Sheng, Fan Wu, Preparation of hemoglobin-loaded nano-sized particles with porous structure as 氧 carriers, Biomaterials, 2007, 28:1414-1422.

22.Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Rheological Properties of Concentrated Aqueous Injectable 钙磷酸盐 Cement Slurry, Biomaterials, 2006, 27: 5003-5013.

23. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Effects of the Granularity of Raw Materials on the Hydration and Hardening Process of Calcium 磷酸盐 Cement, Biomaterials, 2003,24: 4103-4113.

24.Changsheng Liu*, Wei Gai, Songhua Pan, Zisheng Liu, The Exothermal Behavior in the Hydration Process of 钙 Phosphate Cement, Biomaterials, 2003, 24:2995- 3003.

25.Changsheng Liu*, Yue Huang, Jinhua Cui, Kinetics of 羟基磷灰石 Precipitation at pH 10 to 11, Biomaterial, 2001, 22:301-306.

26.Jing Wang, Changsheng Liu*, Yufei Liu, Shuo Zhang, Double-Network Interpenetrating Bone Cement via in situ Hybridization Protocol, Advanced Functional Materials, 2010, 20: 3997-4011.

27.Xiaoqian Shan, Yuan Yuan, Changsheng Liu*, Feng Xu, Yan Sheng, Comparison of the PLA-mPEG and mPEG-PLA-mPEG copolymers nanoparticles on the plasma protein 吸附 and in vivo biodistribution, Soft Matter, 2009, 5, 2875-2883

28.Changsheng Liu*, Wei Shen, Yanfang Gu, Mechanism of Hardening Process for a 羟基磷灰石 Cement, J. Biomed. Mat. Res., 1997, 35(1): 75~80

29.Changsheng Liu*, Wengbo Wang, Wei Shen, Tongyi Chen, Yanfang Gu, Zhongwei Chen, Evaluation of the Biocompatibility of a Nonceramic Hydroxyapatite, J. Endodontics, 1997, 23(8), 490~493

30.Changsheng Liu*, Wei Shen, Effect of 晶体 Seeding on the Hydration of 钙磷酸盐 Cement, J. Mat. Sci: Mat. Med., 1997, 8(12): 803~807

31.Changsheng Liu*, Xingyan Wu, Optimization of Operation Parameters in Ultrafiltration Process, J. Biotech., 1998, 66(2-3):195~202

32.Changsheng Liu*, Wei Shen, Jianguo Chen, Solution Property of 钙磷酸盐 Cement Hardening Body, Mat. Chem. Phys., 1999, 58:78~82

33.Changsheng Liu*, Yue Huang, Haiyan Zheng, Study on the Hydration Process of Calcium Phosphate Cement by AC Impedance Spectroscopy, J. Am. Ceram. Soc., 1999, 82(4):1052-1057

34.Changsheng Liu*, Xingyan Wu, Determination of Membrane 面积 in the Ultrafiltration Process, J. Chem. Technol. Biotechnol., 2001,76(10):1023~1029

35.Changsheng Liu*, Yue Huang, Jianguo Chen, Haiyu Qi, The Physicochemical Properties of the Solidification of 钙磷酸盐 Cement, J. Biomed. Mat. Res. Part B: Appl Biomater, 2004,69B: 73–78

36.Changsheng Liu*，Study on the synthesis and the biological properties of nanometer hydroxyapatite， J　大连市 University，2004，25（2）：42-44

37.Changsheng Liu*, Chien-Wen Chen and Paul Ducheyne，In vitro surface reaction layer formation and dissolution of 钙磷酸盐 cement–bioactive glass composites，Biomed. Mater. 3 (2008)034111（11pp） doi:10.1088/1748-6041/3/3/034111

38.Zhao Jian, Changsheng Liu*. Effect of the crystalline of matrix 均聚物 on release profiles of hemoglobin-loaded nanoparticles. Tissue Engineering, 2006, 12 (4): 1097-1098.

39.Yuan Yuan, Changsheng Liu*, Yuan Zhang，Radio 频率等离子体 Polymers of n- Butyl Methacrylate and Their Drug-Controlled Release Characteristics. I. Effect of the 氧 gas，Surf. Coat. Technol.，2007，201(15)：6861–6864

40.Jing Wang, Changsheng Liu*, Synthesis and properties of chitosan/多肽定制 bioconjugate composite, Biomed. Mater., 2007, 2：32-38

41.Jing Wang, Changsheng Liu*, Ping Chi, Aggregate formation and surface activity of partially deacetylated water-soluble chitin, Research on Chemical Intermediates, 2008, 34(2–3), 169–179

42.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Shiyu Zhang, Xiaoqian Shan, Yan Sheng, Feng Xu. Key parameters affecting the initial leaky effect of hemoglobin-loaded nanoparticles as blood substitutes. J Mater Sci: Mater Med, 2008, 19:2463–2470

43.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Xiaoqian Shan, Yan Sheng, Feng Xu，Reduction and Suppression of Methemoglobin Loaded in the Polymeric Nanoparticles Intended for Blood Substitutes，J Biomed Mater Res Part B: Appl Biomater，2008，87B: 354–363

44.Jing Wang, Changsheng Liu*, Ping Chi. In Situ Preparation of Glycoconjugate Hollow Microspheres Mimetic the Extracellular Matrix via Interfacial Polymerization. International Journal of Biological Macromolecules 2008, 42:450-454

45.Yuan Yuan, Changsheng Liu*, Min Yin, Yuan Zhang. 等离子体 Deposition n- Butyl Methacrylate Coating with Potential for Stent surface Modification. Journal of Materials Science：Material in Medicine, 2008, 19（5）:2187-2196

46.Yuan Yuan, Changsheng Liu*, Yuan Zhang, Xiaoqian Shan, Sol–凝胶 auto-combustion synthesis of 羟基磷灰石 nanotubes array in porous alumina template, Materials 化学 and Physics, 2008, 112: 275–280

47.Xiaolan Zhang, Changsheng Liu*, Yuan Yuan, Xiaoqian Shan, Yan Sheng, Feng Xu. A Noninvasive Method for Measuring the 氧 binding-releasing Capacity of Hemoglobin-loaded Polymeric Nanoparticles Used as Oxygen Carrier. J Mater Sci: Mater Med, 2009, 20: 1025–1030.

48.Xiaoqian Shan, Changsheng Liu*, Yuan Yuan, Feng Xu, Xinyi Tao, Yan Sheng, Huanjun Zhou. In vitro macrophage uptake and in vivo biodistribution of long-circulation nanoparticles with poly(乙烯glycol)-modified PLA (BAB type) triblock copolymer. Colloids and Surface B-Biointerfaces, 2009, 72: 303–311

49.Jing Wang, Changsheng Liu*, Ping Chi. One-Step Preparation of Glycopeptide Microspheres Based on α-Amino Acid-N-carboxyanhydride Polymerization using Interfacial Protocols. Journal of Biomedical Materials Research: Part B, 2009,89B: 45-54

50.Hua Hong, Changsheng Liu*, Wenjing Wu, Preparation and characterization of 几丁聚糖/PEG/鱼胶粉 composites for tissue engineering, J Appl Polym Sci, 2009, 114(2): 1220 - 1225

51.Yan Sheng, Changsheng Liu*, Yuan Yuan, Xiaolan Zhang, Xiaoqian Shan, Feng Xu, Porosity and Semipermeability of Hemoglobin-Loaded Polymeric Nanoparticles as Potential Blood Substitutes, J Biomed Mater Res Part B: Appl Biomater, 2009, 91B: 631–642

52 .Lihua Ma, Changsheng Liu*, Preparation of 几丁聚糖 microspheres by ionotropic gelation under a high voltage electrostatic field for protein delivery. Colloids Surf. B: Biointerf. 2010, 75(2): 448-453

53.Fangping Chen, Changsheng Liu*, Yuhao Mao, 铋doped injectable 钙磷酸盐 cement with improved radiopacity and potent antimicrobial activity for root canal filling, ACTA Biomterialia, 2010, 6: 3199–3207

54.Fangping Chen, Changsheng Liu*, Jie Wei, Xiao Chen, Zhen Zhao, Yanli Gao，Preparation and characterization of injectable 钙磷酸盐 cement paste modified by 聚乙烯 glycol-6000，Materials 化学 and Physics , 2011, 125: 818–824

55.Jiaping Lin, Suning Zhang, Tao Chen, Changsheng Liu, et al., Calcium phosphate cement reinforced by 多肽定制 copolymers, Journal of Biomedical Materials Research , Part B: Applied Biomaterials，2006, 76(2):432~439.

56.Han Guo, Jie Wei and Changsheng Liu*，Development of a degradable cement of 钙磷酸盐 and calcium sulfate composite for bone reconstruction，Biomed. Mater. 2006，1：193–197

57.Hua Hong, Jie Wei, Changsheng Liu*，Development of asymmetric gradational-changed porous 几丁聚糖 membrane for guided periodontal tissue regeneration，Composites: Part B ，2007, 38: 311-316

58.Han Guo, Jie Wei, Yuan Yuan, Changsheng Liu*, Development of 钙硅酸盐 /Calcium 磷酸盐 Cement for Bone Regeneration, Biomed. Mater.，2007，2：S153–S159

59.Xiangqi Qin, Yuan Yuan, Changsheng Liu*, Qiuyun Wang, Xi Shen, Baican Yang, Preparation of Liposomal Brucine and Its Pharmaceutical/Pharmacodynamic Characterization, Acta Pharmacologica Sinica, 2007, 28(11):1851-1858

60.Ping Chi, Jing Wang, Changsheng Liu*，Synthesis and characterization of polycationic 几丁聚糖graft-poly (l-lysine)，Materials Letters, 2008, 62:147–150

61.Yuan Zhang, Yuan Yuan and Changsheng Liu*, Fluorescent Labeling of Nanometer 羟基磷灰石, J. Mater. Sci. Technol. , 2008, 24(2): 187-191

62. Han Guo, Jie Wei, Hang Kong, Changsheng Liu*, and Kefeng Pan, Biocompatibility and osteogenesis of 钙磷酸盐 cement scaffolds for bone tissue engineering, Advanced Materials Research, 2008, 47-50: 1383-1386

63.Kai Wang, Christian Rüssel, Changsheng Liu*, Preparation, mechanical properties and erosion behaviors of oriented Ca(PO3)2 glass-ceramics, 物质s 化学 and Physics, 2008, 111:106113

64.Fan Wu, Jie Wei, Han Guo, Changsheng Liu*, Self-setting Bioactive 钙镁 Phosphate Cement with High strength and Degradability for Bone Regeneration, ACTA Biomaterialia, 2008, 4：1873–1884

65 .Fangping Chen, Kai Wang, Changsheng Liu*，Crystalline structure and its effects on the degradation of linear 钙 polyphosphate bone substitute，Applied surface Science， 2008，255：270–272

66.Kai Wang, Fangping Chen, Changsheng Liu*, Christian Rüssel, The effect of polymeric chain-like structure on the degradation and cellular biocompatibility of 钙 polyphosphate, Materials Science and Engineering C, 2008, 28: 1572–1578

67. Fan Wu, Jiacan Su, Jie Wei, Han Guo，Changsheng Liu*，Injectable bioactive 钙质镁磷酸盐 cement for bone regeneration，Biomed. Mater.，2008，3(4): 044105 (7pp) ，doi:10.1088/1748-6041/3/4/044105

68.Han Guo, Jiacan Su, Jie Wei, Hang Kong, Changsheng Liu*. Biocompatibility and osteogenicity of degradable Ca-deficient 羟基磷灰石 scaffolds from 钙磷酸盐 cement for bone tissue engineering. Acta Biomaterialia, 2009, 5: 268–278

69.Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Combinatorial coating of adhesive 多肽定制 and anti-CD34 antibody for improved endothelial cell adhesion and proliferation, J Mater Sci: Mater Med , 2009, 20:1513–1523

70.Zhengli Xu, Jiao Sun, Changsheng Liu, Jie Wei，Effect of 羟基磷灰石 Nanoparticles of Different Concentrations on Rat Osteoblast, Materials Science Forum, 2009, Vols. 610-613: 1364-1369

71.Yan Sheng, Yuan Yuan, Changsheng Liu*, Xinyi Tao, Xiaoqian Shan, Feng Xu, In vitro macrophage uptake and in vivo biodistribution of PLA–PEG nanoparticles loaded with hemoglobin as blood substitutes: effect of PEG content, J Mater Sci: Mater Med , 2009, 20:1881–1891

72.Jie Wei, Xiaohui Wu, Changsheng Liu*, Junfeng Jia, Su-jin Heo, Seung-eon Kim, Yong-taek Hyun, Jung-Woog Shinw, Fabrication of Bioactive 脚手架 of Poly(e-Caprolactone) and Nanofiber 硅灰石 Composite, J. Am. Ceram. Soc., 2009, 92(5): 1017–1023

73.Feng Xu, Yuan Yuan, Xiaoqian Shan, Changsheng Liu*, Xinyi Tao, Yan Sheng, Huanjun Zhou, Long-circulation of hemoglobin-loaded polymeric nanoparticles as 氧 carriers with modulated surface charges, International Journal of Pharmaceutics, 2009, 377： 199–206

74.Junling Wang, Yuan Yuan, Changsheng Liu*, Di Zhu, Xi Shen, Baican Yang, Preparation and pharmaceutical/pharmacodynamic evaluation of topical brucine-loaded liposomal hydrogel, J Mater Sci: Mater Med, 2009, 20:2075–2084

75.Xiaoqian Shan, Yuan Yuan, Changsheng Liu*, Xinyi Tao, Yan Sheng, Feng Xu, Influence of PEG chain on the complement activation suppression and longevity in vivo prolongation of the PCL biomedical nanoparticles, Biomed Microdevices, 2009, 11:1187–1194

76.Xiaohui Wu, Liang Ye, Kun Liu, Wei Wang, Jie Wei, Fangping Chen, Changsheng Liu*, Antibacterial properties of mesoporous copper-doped silica xerogels, Biomed. Mater. 4 (2009) 045008 (6pp), doi:10.1088/1748-6041/4/4/045008

77.Fangping Chen, Yuhao Mao, Changsheng Liu*, MG Yu. A novel silicate-doped 钙-based composite dental pulp capping agent. Asia-pacific J. Chemical Engineering, 2009, 4(5): 522-527

78 .Xiaoqian Shan, Ligen Chen, Yuan Yuan, Changsheng Liu*, Xiaolan Zhang, Yan Sheng, Feng Xu. Quantitative analysis of hemoglobin content in polymeric nanoparticles as blood substitutes using Fourier transform infrared spectroscopy. Journal of Materials Science: Materials in Medicine, 2010, 21:241–249

79.Lei Wang, Yuanliang Huang, Kefeng Pan, Xinquan Jiang, Changsheng Liu, Osteogenic Responses to Different Concentrations/Ratios of BMP-2 and bFGF in Bone Formation, Annals of Biomedical Engineering, 2010, 38(1): 77–87

80. Yonglin Yu, Jing Wang, Changsheng Liu*, Bingwen Zhang, Honghong Chen, Han Guo, Gaoren Zhong, Weidong Qu, Songhui Jiang, Huangyuan Huang, Evaluation of inherent 毒理学 and biocompatibility of 镁磷酸盐 bone cement, Colloids and Surfaces B: Biointerfaces, 2010, 76: 496–504

81.Guangping Xie, Jiao Sun, Gaoren Zhong, Changsheng Liu, Jie Wei, 羟基磷灰石 nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro, J Mater Sci: Mater Med, 2010, 21:1875–1880

82.Junfeng Jia, Huanjun Zhou, Jie Wei, Xin Jiang, Hong Hua, Fangping Chen, Shicheng Wei, Jung-Woog Shin, Changsheng Liu*, Development of 镁 calcium 磷酸盐 biocement for bone regeneration, J. R. Soc. 接口，2010，7(49): 1171-1180

83. Huanjun Zhou, Jie Wei, Xiaohui Wu, Jianlin Shi, Changsheng Liu*, Junfeng Jia, Chenglong Dai, Qi Gan, The bio-functional role of 钙 in mesoporous silica xerogels on the responses of osteoblasts in vitro，J Mater Sci: Mater Med, 2010, 21:2175–2185

84.Qinghui Zhao, Jiangchao Qian, Huanjun Zhou, Yuan Yuan, Yuhao Mao, Changsheng Liu*, In vitro osteoblast-like and endothelial cells’ response to calcium 硅酸盐/calcium 磷酸盐 cement, Biomed. Mater., 2010, 5: 035004 (9pp), doi:10.1088/1748-6041/5/3/035004

85.Xiaohui Wu, Jie Wei, Xun Lu, Yang Lv, Fangping Chen, Yanglan Zhang, Changsheng Liu*, Chemical characteristics and hemostatic performances of ordered mesoporous 钙-doped silica xerogels, Biomedical Materials, 2010, 5(3):035006 (9pp), doi:10.1088/1748-6041/5/3/ 035006

86.Qingyi Shen, Jiao Sun, Jie Wu, Changsheng Liu, Fangping Chen, An in vitro investigation of the mechanical–chemical and biological properties of calcium 磷酸盐/calcium 硅酸盐/bismutite cement for dental pulp capping, J Biomed Mater Res Part B: Appl Biomater, 2010, 94B:141–148

学术交流

刘昌胜推进国际合作与交流，活跃在生物材料学术前沿领域，是“生物材料与工程学科创新引智基地”（简称“111计划”）负责人，与国际多所大学、研究机构建立了学术合作关系。截至2017年11月，在国际会议上作特邀或邀请报告44次。

代表专利

代表性专利：

(1) Liu Changsheng; Wanli Xing; Jing Wang; Jiangchao Qian; Jing Liang ; Use of fusion protein, 2017-3-14, 美国, US9593151B2

(2) Liu Changsheng; Yuan Yuan ; Nanometer Mesoporous silica-based xerogel styptic material and its preparing process and application, 2014-4-22, 美国, US8703208B2

(3) Liu Changsheng; Lin, Jun; Qian, Jiangchao; Yuan, Yuan ; Optimized DNA sequences encoded recombinant human bone morphogenetic protein-2 (rhBMP-2) and preparation and application of the rhBMP-2, 2011-05-24, 美国, US794821B2

(4) 刘昌胜; 杨凯; 张婧; 袁媛; 李玉林; 马一帆 ; 一种β-TCP/PGS复合支架及其制备方法和应用, 2017-5-1, 中国, 201510012513.9